High EHOMO is essential for reaction with nucleophiles of molecule while low ELUMO is essential for reaction with
electrophiles [44].
This is because the
electrophiles, produced when antioxidants are oxidized, prime the increase of the nucleophilic tone.
Generally,
electrophiles are characterized by high [omega] values [35].
The electrophilicity index ([omega]) is another important parameter [55] which measures the propensity of chemical species to accept electrons; a high value of electrophilicity index describes a good
electrophile while a small value of electrophilicity indicates a good nucleophile.
Our quantitative analysis of the reactivity of redox-sensitive TRP channels revealed that TRPA1 has the highest sensitivity to disulphides among the TRPs that we tested, predicting that only TRPA1 responds to a relatively inert
electrophile, diallyl disulphide, with a redox potential of -2,950 mV.
Yamamoto, "Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to
electrophiles," Free Radical Biology & Medicine, vol.
The ozone is
electrophile and their reactivity decreases in the presence of atoms receptors of electron.
This carbon in an isocyanate is an
electrophile that makes it highly reactive.
Importance of phase 2 gene regulation in protection against
electrophile and reactive oxygen toxicity and carcinogenesis.
The vast majority of RCS, including 4-HNE and MDA, modulate transcription through the Keap1-Nrf2 pathway, which regulates the
electrophile response element/antioxidant response element (EpRE/ARE) [33, 88, 93].
Subsequent tuning of the reactivity and specificity of the
electrophile resulted in the discovery of a class of highly selective Btk inhibitors within the cysteine homolog family.
(29.) Talalay P, Dinkova-Kostova AT, Holtzclaw WD: Importance of phase 2 gene regulation in protection against
electrophile and reactive oxygen toxicity and carcinogenesis.