IBT is currently developing the drug candidate IBP-9414, for the prevention of necrotizing
enterocolitis ('NEC') and improvement of so called feeding tolerance in premature infants.
Necrotizing
enterocolitis. N Engl J Med 2011; 364(3): 255-64.
Extensive Necrotising
Enterocolitis: Objective Evaluation of the Role of Second-Look Laparotomy in Bowel Salvage and Survival.
A review study conducted on 400 preterm babies with a gestational age [less than or equal to] 30 weeks observed a lower prevalence of necrotizing
enterocolitis and retinopathy of prematurity, with no significant differences in weight gain in infants fed maternal milk compared to infants receiving a formula (21).
Bizzarro, "Necrotizing
enterocolitis in newborns: pathogenesis, prevention and management," Drugs, vol.
Bush et al., "Necrotizing
enterocolitis in neonates with congenital heart disease: risk factors and outcomes," Pediatrics, vol.
Bahna, "Clinical manifestations of food protein-induced
enterocolitis syndrome," Current Opinion in Allergy and Clinical Immunology, vol.
Speare, "Staphylococcus pseudomembranous
enterocolitis, a complication of antibiotic therapy," American Journal of Surgery, vol.
Therefore, the aim of the present report was to describe the intestinal microbiome of a patient suffering from Hirschsprung's disease during episodes with and without
enterocolitis and during treatment with probiotics applying 16S rRNA gene next-generation sequencing.
Foreman, "Neutropenic
enterocolitis (typhlitis) in a pediatric renal transplant patient.
There have been concerns that indomethacin can make necrotising
enterocolitis worse, although studies rejected a link.