The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Hemagglutinins

antibodies capable of stimulating the agglutination of red blood cells. Hemagglutinins are subdivided into autohemagglutinins, which act on the blood cells of one’s own body, homohemagglutinins, which act on the red blood cells of organisms of the same species, and heterohemagglutinins, which act on the blood cells of other animal species. Some hemagglutinins are active only against red blood cells suspended in an isotonic sodium chloride solution, and others only in the presence of hydrophilic colloids, such as albumin, or after preliminary action on red blood cells by a proteolytic enzyme. Special hemagglutinins, called frigohemagglutinins, manifest activity only at a temperature of about 4° C.

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References in periodicals archive

A global phylogenetic analysis in order to determine the host species and geography dependent features present in the evolution of avian H9N2 influenza hemagglutinin. PeerJ.

Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential

Think of hemagglutinin as a miniature broccoli stalk.

Remembering 1918 Pandemic: Scientists work to make advances against flu

IAVchip DNA microarray was used to subtype simultaneously the tested IAV with probes specific to hemagglutinin 1-16 and neuraminidase 1-9 genes.

Comparative evaluation of effectiveness of IAVchip DNA microarray in influenza A diagnosis

"This is why universal flu vaccine strategies in recent years have been focused more on the hemagglutinin stem than on the head," noted Damian C.

Unique human antibody can counteract broad range of flu viruses

One of the mutations Kawaoka found in the hemagglutinin molecule may already be helping the virus adapt to humans.

Designer flu: how scientists made a killer virus airborne--and who should know

(2009) Structures of receptor complexes formed by hemagglutinins from the Asian Influenza pandemic of 1957.

Molecular basis of the structure and function of H1 hemagglutinin of influenza virus

Lectins and hemagglutinins can be used as anti-HIV agents, anti-tumor agents and anti-fungal agents.

Isolation and characterization of a French bean hemagglutinin with antitumor, antifungal, and anti-HIV-1 reverse transcriptase activities and an exceptionally high yield

Prediction of mutations in H5N1 hemagglutinins from influenza A virus.

Descriptively probabilistic relationship between mutated primary structure of coagulation factor IX and clinical severity of hemophilia B

The drop in pH alters the shape of the viral hemagglutinin, thereby allowing the virus to fuse to the cell and open an entry for the virus' RNA to come in and start making fresh viruses.

Computer-designed proteins 'may help fight variety of flu viruses'

(11.) Krammer F, Margine I, Tan GS, Pica N, Krause JC, Palese P A carboxy-terminal trimerization domain stabilizes conformational epitopes on the stalk domain of soluble recombinant hemagglutinin substrates.

Hemagglutinin receptor binding of a human isolate of influenza A(H10N8) virus

Perhaps subtype H7N9 virus infection triggered a cross-reactive response between H7 and H3 or H1 hemagglutinins. Primary infection with influenza virus can lead to a heterosubtypic hemagglutinin antibody response (31).

Human antibody responses to avian influenza a(H7N9) virus, 2013

Hemagglutinins of the influenza A(H3N2)v viruses differed substantially from the hemagglutinin of the 2011-12 human seasonal vaccine virus, A/Perth/16/2011 (58-60 aa), which resulted from divergent evolutionary paths for the H3 hemagglutinin in swine and human viruses.

Human infections with novel reassortant influenza A(H3N2)v viruses, United States, 2011