The clinical and histopathological traits of the syndrome resemble those of canine craniomandibular osteopathy (Alexander, 1983; Gulanber et al., 2001; Huchkowsky, 2002) and human infantile cortical hyperostosis (Kamoun-Goldrat and Le Merrer, 2008).
Possible roles of Prostoglandin E1 and E2 have been suggested in some studies, in which elevated levels of serum prostaglandin E was detected in some children with infantile cortical hyperostosis, which is a similar disease to that found in humans in terms of clinical and histopathological aspects.
Infantile cortical hyperostosis (ICH), or Caffey's disease, has a low prevalence, is not easily recognized clinically, and is seldom reported in the primary care literature.