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Inosine

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inosine

[′in·ə‚sēn]
(biochemistry)
C10H12N4O5 A compound occurring in muscle; a hydrolysis product of inosinic acid.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Inosine

 

(hypoxanthine riboside), a nucleoside consisting of the nitride purine base hypoxanthine and the carbohydrate ribose. Inosine is the intermediate product of nucleic acid metabolism. It is formed in the organism during the deamination of adenosine and also by synthesis from a free base according to the reaction hypoxanthine + ribose- 1 -phosphate ⇆ inosine + phosphate. This reversible reaction is catalyzed by the enzyme nucleoside phosphorylase.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
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References in periodicals archive
Effect of mycophenolate mofetil therapy on inosine monophosphate dehydrogenase induction in red blood cells of heart transplant recipients.
Real-time PCR determination of IMPDH1 and IMPDH2 expression in blood cells
Effect of sea buckthorn leaves on inosine monophosphate and adenylocuccinatelyase gene expression in broilers during heat stress.
Comparison of quality traits of meat from Korean native chickens and broilers used in two different traditional Korean cuisines
(3) Nonstandard abbreviations: AZA, azathioprine; TPMT, thiopurine methyltransferase; ITP, inosine triphosphate; ITPA, inosine triphosphate pyrophosphohydrolase; IMP, inosine monophosphate; DTT, dithiothreitol; and CI, confidence interval.
Measurement of erythrocyte inosine triphosphate pyrophosphohydrolase (ITPA) activity by HPLC and correlation of ITPA genotype-phenotype in a Caucasian population
Muscle inosine monophosphate (IMP) content is an indicator meat flavor and adenylosuccinatelyase (ADSL) is a key enzymes regulating IMP synthesis.
Effect of sea buckthorn leaves on inosine monophosphate and adenylosuccinatelyase gene expression in broilers during heat stress
Inosine triphosphatase (ITPA; EC 3.6.1.19) catalyzes the hydrolysis of ITP to inosine monophosphate, thereby recycling purines that might otherwise be trapped in the form of ITP (1, 2).
Rapid detection of ITPA 94C>A and IVS2 + 21A>C gene mutations by real-time fluorescence pcr and in vitro demonstration of effect of ITPA IVS2 + 21A>C polymorphism on splicing efficiency
A study by Kazeniac (1961) indicated that inosine monophosphate (IMP) produced a major contribution to mouth satisfaction and had the effect of intensifying the flavor effects of other compounds.
Effect of caponization on muscle composition, shear value, ATP related compounds and taste appraisal in Taiwan country chicken cockerels
In vitro investigations with recombinant human inosine monophosphate dehydrogenase II-and phytohemagglutinin A-stimulated human peripheral blood mononuclear cells support the concept that the free fraction of MPA is the pharmacologically active form of the drug (6).
Validation of a rapid and sensitive liquid chromatography-tandem mass spectrometry method for free and total mycophenolic acid
Various approaches have been proposed for the pharmacodynamic (PD) monitoring of immunosuppressants: One is evaluation of the activity of the specific target enzyme, such as calcineurin activity (CNA) for cyclosporin A (CsA) and tacrolimus (TRL) (3-5), inosine monophosphate dehydrogenase for MMF (6-8), and P70S6 kinase activity for sirolimus (1, 9).
Pharmacodynamic approach to immunosuppressive therapies using calcineurin inhibitors and mycophenolate mofetil
Effect of mycophenolic acid glucuronide on inosine monophosphate dehydrogenase activity.
Limited sampling strategy for the estimation of mycophenolic acid area under the curve in adult renal transplant patients treated with concomitant tacrolimus
MMF is rapidly metabolized in vivo to its active constituent, mycophenolic acid (MPA), a reversible, noncompetitive inhibitor of inosine monophosphate dehydrogenase.
Comparison of the Emit immunoassay with HPLC for therapeutic drug monitoring of mycophenolic acid in pediatric renal-transplant recipients on mycophenolate mofetil therapy
Intracellularly, MP is converted by hypoxanthine guanine phosphorybosyltransferase into thioinosine monophosphate (TIMP) and subsequently into thioguanosine monophosphate by a two-step process involving inosine monophosphate dehydrogenase and guanosine monophosphate synthetase (2).
HPLC determination of thiopurine nucleosides and nucleotides in vivo in lymphoblasts following mercaptopurine therapy
MMF targets the de novo purine biosynthesis pathway by noncompetitive inhibition of inosine monophosphate dehydrogenase, acting against the proliferation of T and B lymphocytes (1).
Pharmacokinetic basis for the efficient and safe use of low-dose mycophenolate mofetil in combination with tacrolimus in kidney transplantation
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