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colitis

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colitis

, colonitis
inflammation of the colon
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005

colitis

[kə′līd·əs]
(medicine)
Inflammation of the large bowel, or colon.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Colitis

 

inflammation of the colon.

Colitis is one of the commonest diseases of the gastrointestinal tract. It may be caused by infection (dysentery bacilli, salmonellas, amoebas, balantidia), poor food habits, or poisoning (by mercury and other chemicals). It can result from uremic autointoxication or as an independent disease of autoimmune nature (for example, nonspecific ulcerative colitis); in addition, it can arise secondarily from digestive disorders of the stomach and small intestine (gastric achylia, pancreatitis, gastroenteritis). Depending on the cause and severity of the colitis, the changes in the colon may vary from superficial catarrh to necrotic-ulcerative inflammation.

Colitis may be either acute or chronic. Acute colitis is accompanied by general malaise, loss of appetite, spastic abdominal pains, diarrhea, and, sometimes (especially in dysentery), painful straining at stool (tenesmus). The temperature may rise in acute colitis of infectious origin. The feces are pulpy or liquid and mixed with mucus (in severe cases, with mucus and blood). Acute colitis may become chronic.

Chronic colitis is accompanied by loss of appetite, nausea, and general weakness. Dull or paroxysmal abdominal pains often appear before or after defecation. Stool disturbances generally appear as an alternation of constipation and diarrhea. There is a sensation that the abdomen will burst, accompanying borborygmus and copious gas formation. With diarrhea, stools may be passed three or four times a day; they are generally pulpy or liquid and, in severe cases, mixed with mucus and streaks of blood. In spastic colitis, the fecal matter takes the form of small hard lumps. The abdomen is somewhat distended and tender upon palpation along the colon (with spastic constriction). The diagnosis of colitis is confirmed by X-ray examination, proctosigmoidoscopy, and laboratory analysis of the fecal matter.

The treatment of acute colitis (and exacerbations of chronic colitis) involves a starvation or semistarvation diet for one or two days, followed by a mostly protein diet, if fermentative processes are predominant in the intestine, or a carbohydrate diet, if putrefactive processes are predominant. Thereafter, a special colitis diet is recommended (strained, steamed, nourishing foods, with the exception of fruits, vegetables, and fresh milk). Antimicrobial and antiparasitic preparations and preparations that normalize the intestinal flora are indicated for infectious colitis. Therapeutic enemas are prescribed to act on the mucosae in cases of inflammation of the rectum and sigmoid colon. Antispasmodic and cholinolytic agents are used for spasms. Physical therapy (thermal procedures) and sanatorium-health resort treatment (Essentuki, Zheleznovodsk, Piatigorsk, Borzhomi, Morshin) are prescribed for patients with chronic colitis. Surgery is sometimes performed in cases of severe ulcerative colitis. The prevention of gastrointestinal infections, the treatment of diseases of the alimentary canal, and proper diet are helpful in preventing the occurrence of the condition.

REFERENCES

Men’shikov, F. K. Bolezni kishechnika. Moscow, 1962.
Bolezni organov pishchevareniia. Edited by S. M. Ryss. Leningrad, 1966.

A. L. GREBENEV

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
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References in periodicals archive
Song et al., "Predictive factors for severe outcomes in ischemic colitis," Gut and Liver, vol.
The presence of ischemic colitis in young patients should always raise the possibility of drug involvement, especially oral contraceptives, (18) cocaine, (19,20) and migraine medication, like ergotamine derivatives (21) and potentially sumatriptan.
Greenson, "Can ischemic colitis be differentiated from C difficile colitis in biopsy specimens?" The American Journal of Surgical Pathology, vol.
The etiology of ischemic colitis is multifactorial, giving rise to a wide range of clinical presentations depending on the duration and severity of the underlying pathology.
During a median follow-up time of about 18 months, there were 167 cases of ischemic colitis among the IBS patients, compared with 77 cases among the matched controls (90.37 cases per 100,000 patient-years, compared with 41.47 cases per 100,000 patient-years).
Constipation is another risk factor, conferring a 2.6-fold increased risk of ischemic colitis, reported Mark Cziraky, Pharm.D., vice president of HealthCore Inc., a Wilmington, Del.-based research firm.
Alosetron was first approved in 2000 but was withdrawn 8 months later because of 84 cases of ischemic colitis and 113 cases of serious constipation that led to several hospitalizations and 2 deaths.
(from Ischemic Colitis With Atypical Reactive Changes That Mimic Dysplasia [Pseudodysplasia]--Zhang et al)
The microscopic appearance of Shigella, Salmonella, Amebiasis, ischemic colitis, Crohn's disease, antibiotoc-associated colitis, and ulcerative colitis can be quite similar.
Alosetron, approved in 2000 for women with diarrhea-predominant irritable bowel syndrome, is an example of a drug that was withdrawn from the market for safety reasons but brought back with a risk management plan: Months after approval, it was voluntarily withdrawn because of cases of fatal ischemic colitis and severe complications of constipation associated with the drug.
There have been postmarketing reports of hypovolemia, hypotension, and syncope associated with diarrhea and of ischemic colitis and other forms of intestinal ischemia in patients on Zelnorm.
The drug, which returned to the market in 2002, was unavailable for 2 years after it was associated with 84 cases of ischemic colitis and 113 cases of serious constipation; 2 patients in each complication group died.
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