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Isocitric Acid

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isocitric acid

[¦ī·sə¦si·trik ′as·əd]
(biochemistry)
HOOCCH2CH(COOH)CH(OH)COOH An isomer of citric acid that is involved in the Krebs tricarboxylic acid cycle in bacteria and plants.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Isocitric Acid

 

an organic tricarboxylic acid; one of the intermediate substrates of the tricarboxylic acid cycle.

Isocitric acid forms in an organism from citric acid and cisaconitic acid as a result of enzymatic conversion. With involvement of the enzyme isocitrate dehydrogenase, isocitric acid is converted, through oxalosuccinic acid, to α-ketoglutaric acid. With the aid of the enzyme isocitratelyase in the glyoxalate cycle, isocitric acid decomposes to succinic and glyoxylic acids.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
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References in periodicals archive
Dedyukhina et al., "Biosynthesis of citric and isocitric acids from ethanol by mutant Yarrowia lipolytica N 1 under continuous cultivation," Applied Microbiology and Biotechnology, vol.
Morgunov, "Microbiological production of citric and isocitric acids from sunflower oil," Food Technology and Biotechnology, vol.
Yarrowia lipolytica and its multiple applications in the biotechnological industry
For example, both citric and isocitric acids show a main product ion with m/z 111 corresponding to [[M-H-C[O.sub.2]-2 [H.sub.2]O].sup.-]; however, isocitric acid also gives rise to a relatively stable product ion with m/z 155 corresponding to the neutral loss of two water molecules.
Development of a LC-MS/MS Method for the Simultaneous Detection of Tricarboxylic Acid Cycle Intermediates in a Range of Biological Matrices
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