isoleucine

[¦ī·sō′lü‚sēn]

(biochemistry)

C₆H₁₃O₂ An essential monocarboxylic amino acid occurring in most dietary proteins.

The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Isoleucine

α-amino-β-methylvaleric acid, C₂H₅CH(CH₃)-CH(NH₂)COOH, an amino acid discovered by F. Ehrlich (1904), among the decomposition products of fibrin protein; one of the group of branched-carbon-chain monoamino aliphatic monocarboxylic acids.

Isoleucine is present in proteins in only small amounts, but it is an essential amino acid for man, animals, and many microorganisms and must be introduced with food. The daily human requirement of isoleucine is about 1.5 -2 g.

Mentioned in

References in periodicals archive

In the present study, amino acids, including glycine, asparagine, glutamate, threonine, proline, valine, methionine, isoleucine, and histidine, were down-regulated in the HS group, pointing to increased conversion of these metabolites into glucose to maintain homeostasis and supply energy during periods of NEB in dairy cows [22].

Liver metabolic perturbations of heat-stressed lactating dairy cows

The treated group had also reversed direction of changes in some of metabolites levels, including alanine, glutamine, serine, glucose, asparagine, isoleucine, valine, carnitine, isobutyrate and pantothenate compared to AD group which showed the effectiveness of the lavender extract on the improvement of AD rats.

Lavandula angustifolia Effects on Rat Models of Alzheimer's Disease Through the Investigation of Serum Metabolic Features Using NMR Metabolomics

Amino acid g amino acid per 100 g of protein (mean [+ or -] SD) Aspartic acid 8.43 [+ or -] 0.29 Glutamic acid 16.96 [+ or -] 1.34 Serine 3.31 [+ or -] 0.17 Histidine 2.99 [+ or -] 0.09 Glycine 5.64 [+ or -] 0.49 Threonine 5.33 [+ or -] 0.34 Alanine 6.59 [+ or -] 0.41 Arginine 5.88 [+ or -] 0.13 Tyrosine 5.44 [+ or -] 0.16 Valine 4.82 [+ or -] 0.26 Phenylalanine 4.45 [+ or -] 0.12 Isoleucine 5.24 [+ or -] 0.09 Leucine 8.87 [+ or -] 0.87 Lysine 9.84 [+ or -] 0.33 Methionine 2.93 [+ or -] 0.07 Tryptophan 0.59 [+ or -] 0.004 Muscle protein content 67% Table 2.

Contributions to the nutrition of the American crocodile Crocodylus acutus (Cuvier, 1807) in captivity

Peak Retention Amino acids Linear time (min) range ([micro]g/L) 1 8.87 Serine 8.45-101.46 2 10.98 Treonine 8.51-102.06 3 13.49 Arginine 8.36 100.28 4 14.26 Alanine 8.76-105.14 5 16.66 Proline 8.67-104.00 6 24.99 Valine 8.36-100.37 7 25.87 Methionine 8.35-100.19 8 26.95 Cysteine 8.27- 99.30 9 28.29 Isoleucine 8.29 -99.52 10 28.88 Tryptophan 8.30-99.54 Peak A b([10.

Free Amino Acids Analysis in the Venom of the Social Wasp Polistes lanio Under Different Forms of Preservation

Major limitations include incomplete information of all common amino acids and inability to separate leucine from isoleucine and other isobaric analytes.

However, one has to point out the lower content of sulphur amino acids and isoleucine in all fish species analyzed as well as the lower valine content in wels catfish.

Species Variations in the Proximate Composition, Amino Acid Profile, and Protein Quality of the Muscle Tissue of Grass Carp, Bighead Carp, Siberian Sturgeon, and Wels Catfish

The increases for T2DM in leucine, isoleucine, valine, and 3-HIB were significant after BMI adjustment, but those in tyrosine and phenylalanine were not.

Higher Concentrations of BCAAs and 3-HIB Are Associated with Insulin Resistance in the Transition from Gestational Diabetes to Type 2 Diabetes

Isoleucine and leucine were detected as separate peaks in the MDC-CC analysis and replication cohort, and as one peak in the WLWM analysis, thus isoleucine and leucine will be referred as isoleucine/leucine in the WLWM cohort.

Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss

Further biochemical study with plasma amino acid analysis showed a leucine level of 4163.6 [micro]mol/L (reference values: 42-133.1 [micro]mol/L), isoleucine of 499.8 [micro]mol/L (15.1-74.9 [micro]mol/L), and valine of 784.3 [micro]mol/L (73.6--273.1 [micro]mol/L).

Skin Lesions Associated with Nutritional Management of Maple Syrup Urine Disease

Maple syrup urine disease (MSUD) is an autosomal recessive inherited metabolic disease caused by decreased enzyme activity of branched-chain alpha-ketoacid dehydrogenase complex (BCKDC), responsible for catabolism of leucine (leu), valine (val), and isoleucine (isoleu).

A Patient with MSUD: Acute Management with Sodium Phenylacetate/Sodium Benzoate and Sodium Phenylbutyrate