Encyclopedia

Jak-STAT pathway

Jak-STAT pathway

[′jak‚stat ′path‚wā]
(cell and molecular biology)
A rapid signal transduction pathway used by a variety of cytokines and growth factors to alter gene expression. Binding of a cytokine or growth factor to its receptor activates Jak (janus kinase—a cytoplasmic tyrosine kinase) and triggers it to phosphorylate and stimulate STAT (signal transducers and activators of transcription—a gene regulatory protein) to travel to the nucleus and induce transcription of a specific gene.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive
The IFNAR-1 significance can be observed from a study where restored IFNAR-1 expression alone was able to restore defective JAK-STAT pathway, STAT-1 and STAT-3 phosphorylation and anti-HCV response in IFN- resistant cell lines.
Interferon alpha receptors and STAT1 as therapy predictors of a sustained virological response in hepatitis C/B co-infection
Another proinflammatory cytokine, IL-1[beta], is involved in the pathogenesis of the neuropathic pain component of RA regulated by the JAK-STAT pathway [39-41].
Chronic Pain in Inflammatory Arthritis: Mechanisms, Metrology, and Emerging Targets--A Focus on the JAK-STaT Pathway
Kobori, "Interferon-[gamma] biphasically regulates angiotensinogen expression via a JAK-STAT pathway and suppressor of cytokine signaling 1 (SOCS1) in renal proximal tubular cells," The FASEB Journal, vol.
Therapeutic Effects of Tangshen Formula on Diabetic Nephropathy in db/db Mice Using Cytokine Antibody Array
The results could mean "that inhibition of the JAK-STAT pathway may be a new therapeutic target for AD," wrote the study's lead author, Robert Bissonnette, MD, president of Innovaderm Research in Montreal (Br J Dermatol.
Topical tofacitinib shows promise for AD in adult study
When IL-12 is a ligand for the JAK-STAT pathway in macrophages, a proinflammatory response of Th1 is produced, but when IL-10 is present, IL-12's proinflammatory effects are downregulated (Figure 1).
Cytokines as Biomarkers and Their Respective Clinical Cutoff Levels
Progression of liver disease can be controlled by a number of cellular mediators among which JAK-STAT pathway plays a significant role.
DETECTION OF STAT-1 IN PATIENTS CO-INFECTED WITH HEPATITIS B AND C RESISTANT TO INTERFERON
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