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Kallikreins

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The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Kallikreins

 

enzymes of blood plasma and the tissues of certain organs (kidney, pancreas, salivary glands, intestinal walls) that catalyze a reaction in which the quinines bradykinin and kallidin split off from the inactive protein precursor quinino-gen.

Kallikreins are enzymes of the trypsin type. They have ex-tremely narrow specificity and manifest biological activity char-acteristic of the quinines. A preparation of kallikreins from swinepancreas is used as a vasodilator, especially in disorders of peri-pheral blood circulation.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
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References in periodicals archive
Kallikreins and kinins: mediators in inflammatory joint disease?
An Extensive Study of the Functional Polymorphisms of Kinin-Kallikrein System in Rheumatoid Arthritis Susceptibility
As an important element of the kallikrein/kinin system (KKS), tissue kallikrein can cleave low-molecule kininogen into kinins (e.g., bradykinin and kallidin).
The Long-Term Outcome Comparison of Different Time-Delayed Kallikrein Treatments in a Mouse Cerebral Ischemic Model
Kallikreins, a family of secreted serine proteases, have been identified as diagnostic and biomarkers for various malignancies.
MicroRNA-375 Suppresses Extracellular Matrix Degradation and Invadopodial Activity in Head and Neck Squamous Cell Carcinoma
Yousef a postdoctoral scientist at the Toronto Kallikrein Laboratory.
Aggressive ovarian cancer linked to overexpression of five genes. (Quest to Develop Multimodal Screen)
Blood biomarker levels to aid discovery of cancer-related single nucleotide polymorphisms: kallikreins and prostate cancer.
Genetic variation in KLK2 and KLK3 is associated with concentrations of hK2 and PSA in serum and seminal plasma in young men
Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer.
Very low PSA concentrations and deletions of the KLK3 gene
The kallikrein (KLK) [4] family of serine proteases is a putative source of such cancer biomarkers (1, 2).
Copy number and expression alterations of miRNAs in the ovarian cancer cell line OVCAR-3: impact on kallikrein 6 protein expression
Kallikreins and proteinase-mediated signaling: proteinase-activated receptors (PARs) and the pathophysiology of inflammatory diseases and cancer.
Alternative splicing variant of kallikrein-related peptidase 8 as an independent predictor of unfavorable prognosis in lung cancer
A proteolytic cascade of kallikreins in the stratum corneum.
Distribution of 15 human kallikreins in tissues and biological fluids
His main research interests are tumor markers, especially a group of enzymes called human tissue kallikreins. His most recent research focuses on proteomic methodologies for identifying novel cancer biomarkers and the physiology of kallikrein enzymes, as they relate to cancer initiation and progression.
The Morton K. Schwartz Award for significant contributions in cancer research Diagnostics, Sponsored by Siemens Medical Solutions Diagnostics
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