The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Keratoses

a group of noninflammatory diseases of the skin of varied origins whose common manifestation is thickening of the horny layer. The development of keratosis is caused either by hyperplasia (intensified growth) of the horny layer or by increased cohesiveness (knitting) of the cells of that layer; with keratosis the sloughing of scales occurs five to ten times more slowly than in normal skin.

A distinction is made between congenital keratoses, which are due to congenital defects in the processes of cornification (ichthyosis and keratoderma), and acquired keratoses, which arise with various generalized and localized pathological processes (callosity, hypovitaminosis, and endocrine, toxic, syphilitic, gonorrheal, and other processes). Another form are the constitutional keratoses (lichen pilaris and kerosis), which form as a result of the effects of partly congenital and partly acquired unfavorable factors. Treatment of keratoses depends on the causes that produced development of the process.

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References in periodicals archive

Safety and efficacy of hydrogen peroxide topical solution, 40% (w/ w) in patients with seborrheic keratoses: results from two identical, randomized, double-blind, placebo-controlled, phase 3 studies (A-101-SEBK-301 /302).

Advances in Seborrheic Keratosis

As in previous studies, the number of actinic keratoses also declined in the nicotinamide group.

B3 and skin cancers

in their report of Leser-Trelat sign in mother and daughter with breast cancer observed that in their both patients there was sudden appearance of seborrheic keratoses with increased number and s ze after mastectomy and the lesions remains stable long after mastectomy.3Li et al, in their report of Leser-Trelat sign with primary hepatic carcinoma found that at 6-month postoperative follow-up, the lesions of seborrheic keratoses stopped progressing, but did not regress.

Sign of Leser-Trelat: a paraneoplastic sign of internal malignancy

Multiple minute digitate hyperkeratoses: a proposed algorithm for the digitate keratoses. J Am Acad Dermatol.

Multiple minute digitate hyperkeratosis affecting the face and folds: clinical, dermoscopic, and histological report of a familial case

Other topical preparations for actinic keratoses on the market include:

What's old is new again for actinic keratoses treatment

Keywords: Neurofibromatosis, Segmental neurofibromatosis, Eruptive seborrheic keratoses.

A segmental neurofibromatosis case with eruptive seborrheic keratoses

During an average 4-year prospective follow-up conducted at 6-month intervals in the Veterans Affairs Topical Tretinoin Chemoprevention Trial, the 1,131 elderly participants, most of whom were male, developed 3,291 periocular actinic keratoses (AICs).

Eyeglasses may offer periocular AK protection

KEY WORDS: Actinic keratoses, Cryotherapy, Acnalen 0.1% gel.

Comparison of the efficacy of cryotherapy and 0.1% Acnalen gel vs. cryotherapy and placebo in the treatment of actinic keratoses

26 January 2012 - Danish dermatologic and thrombotic drugs developer and marketer LEO Pharma A/S said today the US drug watchdog FDA had cleared Picato (ingenol mebutate) gel (0.015%, 0.05%) to treat actinic keratoses (AK) on the face, scalp, trunk and extremities.

LEO Pharma gets FDA nod for Picato (ingenol mebutate) gel for actinic keratoses

Laser therapy can vaporize the top layer of skin, erasing sandpaper-like spots known as actinic keratoses (AKs) that are caused by sun exposure.

See spots run

The frequency with which carcinoma develops in laryngeal keratoses is controversial.

Laryngeal keratosis with underlying invasive carcinoma

Washington, Dec 1 (ANI): A new study has shown that the NSAID Celebrex may help prevent some non-melanoma skin cancers from developing in patients who have pre-cancerous actinic keratoses lesions and are at high risk for having the disease.

Celebrex shows potential in preventing some skin cancers