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Kinetoplastida

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Kinetoplastida

An order of the class Zoomastigophorea in the phylum Protozoa, also known as Protomastigida, containing a heterogeneous group of colorless flagellates possessing one or two flagella in some stage of their life cycle. These small organisms (5-89 μm in length) typically have pliable bodies. Some species are holozoic and ingest solid particles, while others are saprozoic and obtain their nutrition by absorption.

There is disagreement on the division of the order into families. However, the five or more families can be divided into two general groups (see illustration). The first group contains simple organisms with no distinctive features save one or two flagella of equal or unequal length (includes the families Oikomonadidae, Amphimonadidae, Monadidae, and Bodonidae). The second group contains organisms which have an undulating membrane in addition to one or two flagella (includes Trypanosomatidae and Cryptobiidae). The most important family is the Trypanosomatidae, since it includes several species that infect humans and domestic animals with serious diseases, such as African sleeping sickness. See Cilia and flagella

Representative genera of families of order Kinetoplastidaenlarge picture
Representative genera of families of order Kinetoplastida
McGraw-Hill Concise Encyclopedia of Bioscience. © 2002 by The McGraw-Hill Companies, Inc.

Kinetoplastida

[kə‚ned·ə′plas·tə·də]
(invertebrate zoology)
An order of colorless protozoans in the class Zoomastigophorea having pliable bodies and possessing one or two flagella in some stage of their life.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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References in periodicals archive
Requena, "A postgenomic view of the heat shock proteins in kinetoplastids," FEMS Microbiology Reviews, vol.
Pronin, "New Kinetoplastid species (Kinetoplastida: Kinetoplastidea)" in Index of Animal Species in Inhabiting Lake Baikal and its Area, O.
Lipid biosynthesis pathways as chemotherapeutic targets in kinetoplastid parasites.
This agreement covers kinetoplastid diseases (leishmaniass, Chagas disease, and human African trypanosomiasis), helminth infections (lymphatic filariasis, onchocerciasis and soil-transmitted helminthiasis), and dracunculiasis, fascioliasis and schistosomiasis.
Working in partnership with industry and academia, DNDi has the largest ever R&D portfolio for the kinetoplastid. Since 2007, DNDi has delivered three products, fixed-dose antimalarials "ASAQ" and "ASMQ", and a treatment for the advanced stage of sleeping sickness NECT (nifurtimox-eflornithine combination therapy).
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