Konovalov Reaction

The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Konovalov Reaction

 

the substitution of hydrogen by a nitro group in aliphatic or alicyclic compounds, as well as in the side chain of fatty-aromatic compounds during direct nitration with nitric acid:

R − H + HNO₃ → RNO₃ + H₂O

Specifically, the Konovalov reaction is the nitration with dilute nitric acid (12–20 percent) in the liquid phase at 100°-150°C and elevated or standard pressure. The substitution of hydrogen by a nitro group occurs very easily in the tertiary carbon atom but with considerable difficulty in the primary carbon atom. Fatty-aromatic compounds undergo nitration in the a-position of the side chain.

The Konovalov reaction is used in industry for the preparation of nitro compounds, during which the process is carried out in the vapor phase (> 400°C). M. I. Konovalov discovered the reaction in 1888.

REFERENCES

Reaktsii i metody issledovaniia organicheskikh soedinenii, book 7. Moscow, 1958. Pages 133–222.
Khimiia uglevodorodov nefti, vol. 3. Moscow, 1959. (Translated from English.)

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.