Mild-to-moderate small-droplet steatosis and
Kupffer cell hyperplasia were also seen.
In
Kupffer cells isolated from the rat liver, an increase in the TNF-[alpha] levels after I/R were discovered to be 5 times greater than the increase of the TNF-[alpha] levels in the control group.
Aoyama et al., "Interleukin-17 signaling in inflammatory,
Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice," Gastroenterology, vol.
Dedousis et al., "Depletion of liver
Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance," Diabetes, vol.
D-GaIN inhibits mRNA, and protein synthesis in hepatocytes increased the sensitivity to TNF-alpha released from
Kupffer cells, which activate signaling pathways leading to cellular death.
(5) The classic and non-classic types contain variable amounts of
Kupffer cells. (6)
Lebensztejn, "The role of
Kupffer cells in the morphogenesis of nonalcoholic steatohepatitis--ultrastructural findings.
(17) The formation of a metastatic tumor must also overcome the immune cells of the spleen, such as monocytes and
Kupffer cells. (4) In the rare event that a tumor does seed, imaging modalities such as CT and CT/PET in conjunction with rising CEA levels offers superb diagnostic detection capability.