6 out of 14 patients receiving
LDAC combination achieved an Overall Response Rate (ORR) of 43%, with encouraging duration of response - this data is still maturing.
Median overall survival was 8.3 months (95% CI: 4.4,12.2) for patients treated with Daurismo plus
LDAC compared with 4.3 months (95% CI: 1.9, 5.7) for patients treated with
LDAC alone.
The US FDA's accelerated approval is based on two open-label non-randomized trials in patients with newly-diagnosed AML who were age 75 years or older, or had comorbidities that precluded the use of intensive induction chemotherapy: M14-358, a trial evaluating VENCLEXTA in combination with azacitidine or decitabine, and M14-387, a trial of VENCLEXTA and
LDAC. The efficacy was established based on the rate of complete remission (CR) and duration of CR.
The Audeze Mobius headphone utilises Microchip's IS2064GM-0L3 SoC for the Bluetooth wireless connection supporting
LDAC and other audio codec interfaces.
LDAC is able to send three times the amount of data through existing Bluetooth technology than typical formats.
LDAC is rare and is primarily associated with LV aneurysms that are not explained by vascular events.
Background: Canadian Blood Services formed the
LDAC group with the goals of:
Youth with disabilities constitute an increasingly educated, yet underrepresented social group in today's knowledge-based economy, and have become an increasingly important at risk group for educators and policymakers (CAF 2004; HREOC 2005;
LDAC 2005; NCD 2007; Roeher Institute 2004).
Although not as established, liquid desiccant air conditioning (
LDAC) systems using 180[degrees]F-210[degrees]F (82[degrees]C-99[degrees]C) hot water are beginning to make an appearance in supermarkets.
