Lentigo maligna--challenges, observations, imiquimod, confocal microscopy, and personalized treatment.
(95,96) An intraepidermal component can be present in both desmoplastic nevi and desmoplastic melanoma, but can be helpful if it is clearly malignant (often showing morphologic features of
lentigo maligna) (Figure 7, C).
The non-tumorigenic radial growth phase encompasses the intraepidermal lesions, namely
lentigo maligna and in situ melanoma (M), and the microinvasive forms including ultra-thin M and the vast majority of thin M.
Where specific histological subtype was recorded, superficial spreading melanoma predominated with 47% cases, followed by nodular (20%), acral lentiginous (11%) and
lentigo maligna melanoma (9%).
She had been diagnosed with pre-cancerous '
lentigo malignia' on her face
[5] There are four main types of malignant melanoma: (a) Superficial spreading malignant melanoma which is the most common among Caucasians and accounts for 70% of all melanomas occurs in adults and may develop anywhere on the body but appears with increased frequency on the upper back of both men and women and on the legs of women, (b) nodular melanoma (15-30% of all melanomas) tends to rapidly invade the dermis from the onset with no apparent horizontal growth phase, (c)
lentigo maligna melanoma (4-10% of all melanomas) originates from
lentigo maligna, [6] and (d) acral lentiginous melanoma (2-8% of all melanomas) occurs on the palmar and plantar surfaces, the digits, and the sublingual areas.
(12) Type % of cases Superficial spreading melanoma 70 Nodular melanoma 15
Lentigo maligna melanoma 13 Acral lentiginous melanoma 2-3
Lentigo maligna (LM) is a form of melanoma in situ that occurs on exposed sun-damaged skin of elderly people [1].
Impetigo 1 Lentigines 1 Louse 1 Pityriasis rosea 1 Scabies 1 Seborrhoeic dermatitis 6 Senile pruritus 1 Solar
lentigo 2 Venous ulcer 1 Vitiligo 1 Note: Table made from bar graph.
Cutaneous melanoma is not a single neoplastic disease, since it consists of several subtypes, such as superficial spreading melanoma,
lentigo maligna, acral lentiginous melanoma, and nodular melanoma.
The activation of melanocytes can also be idiopathic, such as in ethnic-type nail pigmentation,
lentigo of the nail apparatus, and Laugier-Hunziker syndrome [3, 5-7].
Results: Common pigmented skin lesions included seborrheic keratosis (SK), solar
lentigo, freckles, blue nevi, melanocytic nevi, dysplastic nevi etc.