In this study, we identified two novel heterozygous variants in the LHCGR gene (c.349G>A, p.Gly117Arg and c.878C>A, p.Ser293 (*)) causing type 1
Leydig cell hypoplasia in a 2.75 year old patient presenting with female external genitalia and bilateral testis tissue in the inguinal region.
In the present study, although the consumption of BD1/2 elevated the number of
Leydig cells, in line with the increased testosterone level they produced, the expected volume increase in the interstitial tissue was not observed.
The submucosa consists of loose fibrous connective tissue containing many hemolymphatic vessels and
Leydig cells. Occasional cells containing faint gray-brown granules are present in the submucosa, as are scattered hemocytes (Fig.
It has been showed that the carbamate insecticide carbaryl has affected spermatogenic cells and caused
leydig cells degeneration and altered serum testosterone and gonadotrophin levels (Shrivastava and Shrivastava, 1998).
Since NOS isoforms are present in
Leydig cells, we assumed that L-NAME, a non-selective NOS inhibitor, would block NO synthesis and, consequently, a possible basal nitrergic inhibition of purinergic currents.
Effects of submaximal training and anabolic androgenic steroids administration on steroidogenic enzyme activity in rat
Leydig cells. Folia Med (Plovdiv) 2003; 45:37-40.
Tavassoli, "Hepatocytic differentiation in retiform Sertoli-Leydig cell tumors: distinguishing a heterologous element from
Leydig cells," Human Pathology, vol.
Ishikawa reported that in humans, the leptin receptor is present in testicular tissue and confined only to
Leydig cells and is not expressed by Sertoli cells, germ cells, or spermatozoa [28].
Effect of retinol and retinoic acid on testosterone production by rat
Leydig cells in primary culture.
Showing the positive immunolocalization of testicular phosphotyrosine in sustentocytes (Sertoli cells) (A'), spermatogonia (B'), round and elongated spermatids (C'), and interstitial endocrine cells (
Leydig cells) (D') as compared to negative control (A, B, C, and D).
Steroidogenic
Leydig cells and apoptotic cells were labeled in cultured explants of GW 10-12 human fetal testis with an immunostaining of CYP11A1 (left panel) and an anticleaved caspase-3 antibody (right panel), respectively.
One primary cause is the dysfunction of testosterone-producing
Leydig cells in the testes.