This last step is very slow thus resulting in accumulation of formic acid in the body which leads to life threatening
metabolic acidosis. Another postulated mechanism is the low hepatic levels of these enzymes in humans leading to methanol intoxication.
An integrative view of findings at the start of the first dialysis of the week showed slight acidemia (mean pH 7.32 [+ or -] 0.05), mean bicarbonate concentration of 17.5 [+ or -] 2.3 mEq/L, and an adequate respiratory response for the level of chronic
metabolic acidosis (mean difference between measured and expected pC[O.sub.2] values, 2.1 mEq/ L).
Metabolic tests were analyzed for inborn error of metabolism due to
metabolic acidosis, hypoketotic hypoglycemia, hyperammonemia, and elevated liver enzymes.
Metabolic acidosis in pregnancy may be life-threatening to both the mother and the fetus.
The patient was orotracheally intubated due to
metabolic acidosis with high anion gap, which was treated using NaHC[O.sub.3].
In
metabolic acidosis caused by methanol intake, particularly when pH drops below 7.2, myocardial contractions are suppressed and serious arrhythmias may be observed (6, 7).
Hemodialysis was started two hours after admission due to persistent severe
metabolic acidosis and electrolyte imbalance.
The reported results showed a high prevalence of
metabolic acidosis and higher partial pressures of oxygen when compared with a healthy population; nevertheless, the conditions of the dialytic treatment were different from those of today, since the standard hemodialysis solution contained 36.6 mmol/L of acetate and high-flux; high-efficiency filters were not available [8].
However, bicarbonate treatment is widely used to stabilise
metabolic acidosis in cases of metformin poisoning as described in the literature.
Based on Table 2,
metabolic acidosis was first managed with fluid replacement and sodium bicarbonate while searching for possible causes of lactic acidosis.
Malnutrition may be related to
metabolic acidosis due to increased protein catabolism, decreased protein synthesis, endocrine abnormalities, and inflammation among dialysis patients [37].