Further modifications of the antipyrine molecule aiming at improving its analgesic and antipyretic properties gave origin to various pharmaceuticals, such as aminophenazone (aminopiryne or amidopyrine), propyphenazone, dipyrone (
metamizole), and phenylbutazone (1).
The pain was initially addressed with
metamizole and oxycodone, which were later exchanged for a buprenorphine transdermal patch.
Metamizole was used in 8-9% of cases, followed by other analgesics such as paracetamol, flunixin meglumine, and butorphanol.
Therewithal, Korkmaz et al.20 demonstrated that 1g IV pre-emptively paracetamol in addition to morphine PCA provided effective equivalent analgesia to 1g of
metamizole after lumbar disc surgery.
Patient painkiller intake was divided into three categories: category A, per os: dipyrone 1 g (
metamizole in the United States), acetaminophen 1 g, or oxycodone 5 mg and naloxone 2.5mg); category B, per os: oxycodone 5mg and acetaminophen 325 mg or tramadol 50 mg; and category C, intravenous: tramadol 100 mg.
For POP treatment following gynaecological surgery, basic analgesia was provided by the nonopioid analgesics acetaminophen, ibuprofen, and
metamizole. In cases of expected moderate-to-severe pain, opioids were added, including oral tramadol or parenteral piritramide, applied via patient-controlled analgesia pumps.
The dipyrone
metamizole is a popular analgesic, nonopioid drug, which is commonly used in human and veterinary medicine for pain management in patients where nonsteroidal anti-inflammatory drugs (NSAIDs) are contraindicated [1].
Metamizole sodium was injected as a postsurgical analgesic and added to the drinking water for 3 days after.
After 4 days under pharmacological management (dexamethasone,
metamizole, ephedrine, clindamycin, and midazolam), together with assisted mechanical ventilation, the extubation could finally be performed.