The mixture solvent contains ethyl acetate that acts as a solvent and a specific reagent for paracetamol (ferric chloride, Folin-Ciocalteu reagent, Nessler's reagent, and Lieberman reagent).
The colorimetric sensing ability of reagent of paracetamol (ferric chloride, Folin-Ciocalteu reagent, Nessler's reagent, and Lieberman reagent) was investigated by adding paracetamol to the reagent solution.
Table 1 shows that the solution color changed after paracetamol was added to the Fe[Cl.sub.3], Folin-Ciocalteu, and Nessler's reagent. Fe[Cl.sub.3] gives blue and black colors, and the Folin-Ciocalteu gives a dark blue color when this reagent is reacted with phenol on paracetamol.
All of the specific reagents for paracetamol (ferric chloride, Folin-Ciocalteu reagent, and Nessler's reagent) are water soluble.