pestis to express various proteins enabling escape of the
phagolysosome in a diverse array of phagocytic cells including human macrophages (25-27); and prior associations between Y.
Finally, (8) fusion with LAMP-1-lysosome and (9)
phagolysosome formation with fungal killing occur.
McCormack, "Keratinocyte growth factor administration attenuates murine pulmonary mycobacterium tuberculosis infection through granulocyte-macrophage colony-stimulating factor (GM-CSF)-dependent macrophage activation and
phagolysosome fusion," The Journal of Biological Chemistry, vol.
(14) The best-known member of the genus is Coxiella burnetii, the causative agent of Q fever, a worldwide zoonotic disease that infects the
phagolysosome of macrophages.
marinum), survive in macrophages by preventing both
phagolysosome formation [40] and recruitment of LC3 to its phagosome [41].
The virB operon is essential for non-opsonized Brucella that continues to live within the
phagolysosome and to create a successful intracellular replicative compartment (Lopez-Goni and Moriyon, 2004) and modulates Brucella intracellular trafficking (Comerci et al., 2001; Delrue et al., 2001).
(25) TlyA can orchestrate intra-cellular survival by modulating the
phagolysosome maturation especially, during the initial stages of establishment of infection, while other pathogenic factors may come into play at a later point of time for the successful establishment of disease.
These is the case of Enterobacter aerogenes, Aeromonas hydrophila and Legionella pneumophila, which have been observed to survive within vacuoles of Acanthamoeba castellanii, inhibiting the fusion of the
phagolysosome [27].
During this time, the bacilli resist the bactericidal mechanisms of the macrophage (
phagolysosome) by preventing phagosome-lysosome fusion, multiply in the phagosome, and cause macrophage necrosis [5].
The
phagolysosome in the phagocytes of coelomate animals contains a variety of hydrolases, including phosphatases (alkaline and acid), lipases and esterases with varying substrate specificity, and an array of substrate-specific glycosidases (reviewed in: Borregard et al., 1993; Hayhoe and Quaglino, 1994).