Pick disease is a typical 3R tauopathy; CBD, PSP, AGD, and multisystem atrophy with globular inclusions belong to 4R tauopathies; and diffuse neurofibrillary tangle dementia with calcifications, to 3R + 4R tauopathies.
3R Tauopathy: Pick Disease.--The macroscopic examinations of brains with Pick disease often show severe, circumscribed lobar frontal and temporal atrophy that may be either symmetric or asymmetric.
In majority of children, bone marrow was infiltrated by lymphoma (Figure 1A, 1B), followed by neuroblastoma (Figure 2A, 2B), Neimann
Pick Disease (Figure 3), Gaucher's disease (Figure 4), rhabdomyosarcoma (Figure 5A, 5B) and Langerhans Cell Histiocytosis (Figure 6).