Frequency is pioneering a new class of small-molecule therapeutics designed to activate
progenitor cells already present within the body to create healthy functional tissues and organs.
Berweiler et al., "Estrogen increases bone marrow-derived endothelial
progenitor cell production and diminishes neointima formation," Circulation, vol.
The body's endothelial
progenitor cells repair the damage to the lining of the arteries that leads to cardiovascular disease.
Hybrid vitronectin-mimicking polycaprolactone scaffolds for human retinal
progenitor cell differentiation and transplantation.
According to the new Services Agreement,
Progenitor Cell Therapy will produce clinical supplies of ICT-140, a dendritic cell vaccine targeting seven ovarian cancer antigens, using process improvements.
A strong, positive correlation was identified between coronary collateral flow and the number of circulating CD34+/CD133+ endothelial
progenitor cells in patients with CAD.
The deal has already received support from the owners of above 50% in both NeoStem and
Progenitor Cell Therapy.
The human
progenitor cell antigen (CD34) is localized on endothelial cells, dermal dendritic cells and peri-follicular cells in formalin--fixed normal skin, and on poliferating endothelial cells and stromal spindle--shaped cells in Kaposi's Sarcoma.
(7,8) Jones and Corwin have proposed that a subpopulation of cells localized in the supporting cell layer in mammals may be
progenitor cells that are responsible for limited hair cell regeneration in vestibular organs such as the utricle.
CBMG's allogeneic adipose-derived mesenchymal
progenitor cell (haMPC) AlloJoin product is an off-the-shelf stem cell therapy developed completely in -house by CBMG over the past 7 years.
Founded by pioneers in the field of regenerative medicine and drug delivery technology, Frequency's
Progenitor Cell Activation Regeneration platform uses a combination of small molecules to stimulate
progenitor cells within the body to repair diseased or damaged tissue.
In order to understand how progenitors decide where to go in the noisy environment of animal regeneration, the researchers used the planarian eye, a visible organ that is small enough to be removed without serious injury and has the added advantage of having defined
progenitor cell molecular markers.