McMahon, "Photoperiod programs dorsal
raphe serotonergic neurons and affective behaviors," Current Biology, vol.
In relation to the prosencephalon, immunohistochemical studies have shown that serotonergic neurons arising in the dorsal
raphe nuclei are projected via the medial forebrain bundle to the striatum and cortex (85).
Nectow and his colleagues zeroed in on the dorsal
raphe nucleus, or DRN, when whole-brain imaging made with iDISCO, an advanced technique developed at Rockefeller, revealed that this part of the brain becomes activated in hungry mice.
An orexinergic projection from perifornical hypothalamus to
raphe pallidus increases rat brown adipose tissue thermogenesis.
Ultrasound of the scrotum demonstrated redundant soft tissue in the perineum inferior to the
raphe. The bulge restricted the patient's daily activity and he opted for surgical excision.
RVM: rostral ventromedial medulla; MD: mediodorsal thalamic nucleus; PFC: prefrontal cortex; ACC: anterior cingulate cortex; DR: dorsal
raphe nucleus; DMH: dorsomedial hypothalamic nucleus; AVP: arginine vasopressin; CNF: corticotropin releasing factor; GFAP: glial fibrillary acidic protein; WDR: wide dynamic range neurons; BK: bradykinin; PG: prostaglandins; [beta]-EP: [beta]-endorphin; (-): inhibition of cell discharge; NTS: nucleus of the solitary tract; TNF-[alpha]: tumor necrosis factor-[alpha]; NK1R: neuropeptide K1R; SP: substance P; ENK: enkephalin.
This idea could be corroborated using two tools also developed by the Anatomic Gene Expression Atlas-AGEA (http://www.brain-map.org/agea/) that shows a correlation in gene expression in nearby areas [4] as shown in Figure supplementary S9 and the expression of one connectivity marker injected in the dorsal
raphe nucleus shown in Figure supplementary S10.
Jouvet," Afferent projections to the rat nuclei
raphe magnus,
raphe pallidus and reticularis gigantocellularis pars a demonstrated by iontophoretic application of choleratoxin (subunit b)," Journal of Chemical Neuroanatomy, vol.
The
raphe nucleus appeared uninterrupted and was rated as normal.
Among those structures, the mesolimbic pathway, the locus coeruleus, and the
raphe nuclei can be damaged.