Anti-neutrophil cytoplasm antibodies and anti-glomerular basement membrane antibodies: two co-existing distinct autoreactivities detectable in patients with
rapidly progressive glomerulonephritis. Am J Kidney Dis.
Rapidly progressive glomerulonephritis did not explain the CNS symptoms, and a normal prothrombin time and activated partial thromboplastin time ruled against disseminated intravascular coagulation (5).
Renal ultrasound is normal, but preliminary renal biopsy shows
rapidly progressive glomerulonephritis. The internist immediately starts dialysis, cyclophosphamide at 1,5 mg/kg, and prednisone, 1 mg/kg.
Crystalline silica exposure has been linked to rheumatoid arthritis, scleroderma, systemic lupus erythematosus,
rapidly progressive glomerulonephritis and some of the small vessel vasculitides.
Rapidly progressive glomerulonephritis: Classification, pathogenetic mechanisms, and therapy.