relaxin

[ri′lak·sən]

(biochemistry)

A hormone found in the serum of humans and certain other animals during pregnancy; probably acting with progesterone and estrogen, it causes relaxation of pelvic ligaments in the guinea pig.

The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Relaxin

a hormone formed mainly in the ovaries that produces relaxation of the ligaments of the pubic symphysis of the pubic bones during pregnancy; as a result, the pelvis widens and normal childbirth is facilitated. Relaxin also characteristically inhibits the spontaneous contractions of the uterus.

Chemically relaxin is a polypeptide. Refined sow relaxin exhibits pronounced basic properties; it has molecular weight of about 6,500 and a structure of two subunits, consisting respectively of 22 and 28–31 amino-acid residues, joined by a disulfide bond. The primary structure has not been determined. The biosynthesis of either relaxin or the polypeptides that are closely related to it structurally is also possible in tissues found in the uterus and placenta.

Mentioned in

Thirst and sodium appetite

References in periodicals archive

There's a huge change after your first child - physically and mentally you are a different person My body was used to being stiff like a coiled spring, so the pregnancy hormone relaxin really affected me

Pregnancy almost ended my Olympic dream; JESSICA ENNIS-HILL; EXCLUSIVE

SHERWOOD et al., 1978 Subcutaneous (SC) P4 injections did not influence relaxin peak and beginning of lactation.

Prepartum progestagen supplementation in swine: a strategy to facilitate piglet care and prevent early parturition/Suplementacao de progestagenos no pre-parto em suinos: estrategia para facilitar assistencia aos leitoes e evitar partos precoces

Bussey, "Pregnancy-related pelvic girdle pain and its relationship with relaxin levels during pregnancy: a systematic review," European Spine Journal, vol.

An Atraumatic Symphysiolysis with a Unilateral Injured Sacroiliac Joint in a Patient with Cushing's Disease: A Loss of Pelvic Stability Related to Ligamentous Insufficiency?

Pathogenetic relevance of the pregnancy hormone relaxin to inborn hip instability.

Bilateral staged total hip replacement and the natural progress of an untreated case of developmental dysplasia (dislocation) of the hip: a clinical case report by the surgeon and the patient

Variations in serum relaxin (hRLX-2) concentrations during human pregnancy.

The role of ultrasound in diagnosis of the causes of low back pain: a review of the literature

Jeong et al., "Relaxin augments BMP 2-induced osteoblast differentiation and bone formation," Journal of Bone and Mineral Research, vol.

The importance of the prenyl group in the activities of osthole in enhancing bone formation and inhibiting bone resorption in vitro

Kaminska et al., "Assessment of VEGF-receptor system expression in the porcine endometrial stromal cells in response to insulin-like growth factor-I, relaxin, oxytocin and prostaglandin E2," Molecular and Cellular Endocrinology, vol.

Interleukins affect equine endometrial cell function: modulatory action of ovarian steroids

In the biomarker analysis from the Relaxin in acute heart failure (RELAX-AHF) development program [16], changes in markers of cardiac (hsTnT), renal (pCr and cystatin-C), and hepatic (aspartate transaminase and alanine transaminase) damage and of decongestion (NTproBNP) at day 2 improved with Serelaxin administration.

High-sensitivity troponin T: a biomarker for diuretic response in decompensated heart failure patients

McTiernan et al., "Relaxin suppresses atrial fibrillation by reversing fibrosis and myocyte hypertrophy and increasing conduction velocity and sodium current in spontaneously hypertensive rat hearts," Circulation Research, vol.

Duration of electrically induced atrial fibrillation is augmented by high voltage of stimulus with higher blood pressure in hypertensive rats

THANK YOU DISTRICT 1 for your "Relaxin Memphis Style" basket.

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