For instance, ADC with disulfide-linkage has been shown to have more cytotoxic activity than the same ADC with
thioether linkage when they were directed to the tumor cell lines expressing a low copy number of targeted antigen (17).
Zhu, Novel 1,3,4-oxadiazole
thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents, Bioorg.
At first it is slowly and almost completely converted to 6-mercaptopourine (6-MP) by reductive cleavage of the
thioether. This is mediated by glutathione and similar compounds in the intestinal wall, the liver and on red blood cells, without the aid of enzymes [7].
Identification of
thioether intermediates in the reductive transformation of gonyautoxins into saxitoxins by thiols.
Kadcyla is an antibody-drug conjugate consisting of trastuzumab covalently linked to the microtubule inhibitor, DM1 (mertansine) via a non-reducible
thioether linkage (MCC).
Chelation in metal intoxication XXVII: chelating agents containing vicinal
thioether groups as antidotes of lead toxicity.
Prenylation is a type of lipid modification involving covalent addition of either farnesyl (15-carbon) or more commonly geranyl-geranyl (20-carbon) isoprenoids by
thioether linkages to cysteine residues at or near the C terminus of intracellular proteins.
Clear transport selectivity for silver(I) ion was observed using both
thioether donor macrocycles.