On the other hand, for distilled water sample,
thymine caused the highest decrease in pH values (Table 2).
THYMINE AND URACIL LESIONS AS THE SOURCES OF ARTIFACTUAL T790M MUTATIONS
Thymine (99%), vinylbenzyl chloride (VBC) (90%), and butylated hydroxytoluene (BHT) (99%) were purchased from Sigma-Aldrich.
The compounds
thymine (T), adenine (A), uracil(U), cytosine (C)guanine (G) 99% purity were purchased from sigma Chemicals Co.
Thymine DNA glycosylase is a positive regulator of Wnt signaling in colorectal cancer.
Sequencing of a portion of exon 2 of the DSPP gene revealed a
thymine to guanine transversion at nucleotide 16 associated with the development of dentin dysplasia type II.
We know -- we see again -- that from the universal genetic alphabet of adenine,
thymine, cytosine and guanine, endless variety has sprung and keeps springing.
The synthetic route to uracil and
thymine nucleosides involves the steps illustrated in Scheme 4 and started with the preliminary preparation of the isocyanates whose quality and purity strongly determine the yields of the final compounds.
The two complimentary pairs of nucleobases, adenine with
thymine and cytosine with guanosine, have long been considered thekey to DNA'sstability, replication, and capacity for information storage, with the hydrogen bonds between them playing an integral role.
The formation of excimers is important not only to understand the distinct photophysics of oligonucleotides and DNA but also to account for the intrinsic and distinct photoinduced reaction of cytosine and
thymine, which form CPDs.
(6) On the other hand, the presence of
thymine in nt 1858, forming a base pair with the adenine in nt 1896, makes the encapsidation signal of the pre-genomic RNA stronger.
