Its effect was blocked by
tolazoline ([10.sup.-9] M) and propranolol ([10.sup.-9] M).
Typical ECMO Criteria Across Centers Weight greater than 2,000 g Gestational age greater than 34 weeks Reversible lung disease No more than 7 to 10 days of ventilator therapy No major intracranial hemorrhage No congenital abnormality incompatible with life Failure of maximal medical management Examples: 100% oxygen Hyperventilation/alkalosis
Tolazoline treatment Some evidence of severe respiratory failure Examples: Alveolar-arterial oxygen gradient [is greater than] 600 for 12 hr or [is greater than] 610 for 8 hr Oxygenation Index [is greater than] 40 on 3-5 arterial gases 1/2 hr apart Barotrauma or air leaks Evidence of acute deterioration Example: Pa[O.sub.2] [is less than] 40 torr for 2 hr Notes: Pa[O.sub.2] = partial pressure of oxygen; torr = millimeters of mercury.
We fitted each animal with a mortality-sensitive very high frequency (VHF) telemetry collar (Advanced Telemetry Systems, Isanti, MN, USA); carfentanil citrate and xylazine hydrochloride were reversed with naltrexone and
tolazoline. We relocated radio-collared pronghorn from the ground weekly with a hand-held telemetry receiver from March 2010 through June 2011 (model R-1000, Communications Specialists, Orange, CA, USA) and recorded locations using a hand-held global positioning system (GPS).
Immobilized bears were then given 1.8 mg/kg of
Tolazoline at 1 to 1.5 h after induction m reverse the effects of xylazine HCL.
Moose were tranquilized with a mixture of carfentanil citrate and xylazine hydrochloride and were antagonized with a mixture of naltrexone hydrochloride and
tolazoline hydrochloride given intravenously.
After being immobilized for 90 min, all deer captured through darting received a 400 mg injection of
tolazoline hydrochloride (Tolazoline[R], Lloyd Laboratories, Shenandoah, Iowa, USA) to reverse the effects of the immobilization agent.