(2011) Intra-acinar
trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis.
Yamamura, "Autophagy and acute pancreatitis: a novel autophagy theory for
trypsinogen activation," Autophagy, vol.
Effect of Janus kinase 2/signal transducer and activators of transcription 3 signaling pathway on the release of high mobility group box 1 in
trypsinogen activation peptide-induced rat pancreatic acinar cells.
TAP is released, with activation of
trypsinogen to trypsin, and plasma and urine levels are known to correlate with severity of pancreatitis.
In a murine model of necrotizing pancreatitis, UTCZP- (CUZD1-) deficient mice developed more severe pancreatitis suggesting that CUZD1 may play an important role in
trypsinogen activation and in the severity of pancreatitis [75].
NFAT, and especially the variant NFATc3, were found to regulate the activity of
trypsinogen (a precursor form of the digestive enzyme trypsin), which can affect the risk of acute pancreatitis.
It converts
trypsinogen to trypsin, indirectly activating a number of pancreatic digestive enzymes.1,2 Enterokinase is a key enzyme for intestinal digestion of proteins.
Screening tests include sweat conductivity measurement and newborn testing for immunoreactive
trypsinogen (universal screening is not currently done in South Africa).
Trypsin is secreted as the zymogen
trypsinogen; it is converted in the intestine into the active enzyme trypsin by an enzyme called enterokinase.
Cystic fibrosis is one of the conditions included in the screening, and it has two components: measurement of immunoreactive
trypsinogen (IRT), an enzyme produced by the pancreas, and if elevated, an assessment of some of the most common genetic mutations causing CF.
Mutations in the gene coding for cationic
trypsinogen cause hereditary pancreatitis.
In the animal pancreas, the acinar cells synthesize and store the proteolytic components as inactive precursors such as
trypsinogen and chy-motrypsinogen, to protect the gland itself.