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tumor necrosis factor

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tumor necrosis factor

[¦tü·mər nə′krō·səs ‚fak·tər]
(immunology)
A monokine that induces leukocytosis, fever, weight loss, the acute-phase reaction, and necrosis of some tumors.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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References in periodicals archive
Recombinant human tumor necrosis factor receptor (etanercept) for treating ankylosing spondylitis: a randomized, controlled trial.
Buee et al., "Elevated circulating tumor necrosis factor levels in Alzheimer's disease," Neuroscience Letters, vol.
Tumor necrosis factor infusions have a procoagulant effect on the hemostatic mechanism of humans.
Serum concentrations of tumor necrosis factor [alpha] in childhood chronic inflammatory bowel disease.
Certain cytokines (interleukin [IL]-1 and tumor necrosis factor [TNF]-[alpha], but not viral replication, correlate with cardiac inflammation and can overcome resistance to chronic myocarditis (7-9).
(Rockville, MD) has patented Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have been shown to bind TRAIL.
Changes in left ventricular ejection fraction (LVEF), flow-mediated vasodilation, plasma high-sensitive interleukin 6 and high-sensitive tumor necrosis factor, and exercise peak oxygen consumption were assessed.
BARCELONA -- Nearly 100 cases of drug-induced lupus have been reported in patients treated with anti tumor necrosis factor agents, Dr.
Targeted Genetics Corporation (Seattle, WA) obtained a patent covering both intramuscular and intravenous routes of delivery of a tumor necrosis factor (TNF) antagonist to lower levels of, and treat symptoms related to, elevated levels of TNF, an inflammatory cytokine associated with several inflammatory diseases in mammals.
Elevated serum concentrations of tumor necrosis factor (TNF)-alpha (44 pg/mL; normal <15.6 pg/mL), interleukin (IL)-[1.sup.2] (129 pg/mL; normal <3.9 pg/mL), IL-6 (3,415 pg/mL; normal <3.1 pg/mL), IL-8 (15,598 pg/mL; normal <31.2 pg/mL), and granulocyte-colony stimulating factor (G-CSF) (165,000 pg/mL; normal <39.1 pg/mL) were observed.
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