De Craen, "Is the assumed natural history of
vulvar intraepithelial neoplasia III based on enough evidence?
HPV-negative
vulvar intraepithelial neoplasia (VIN) with basaloid histologic pattern: an unrecognized variant of simplex (differentiated) VIN.
Treatment with the vaccine resulted in important T-cell responses in most patients after two vaccinations in the phase II study of women with histologically proven
vulvar intraepithelial neoplasia (VIN).
Differentiated
Vulvar Intraepithelial Neoplasia.--A small proportion of
vulvar intraepithelial neoplasia (VIN) cases are unrelated to HPV infection and have been associated with lichen sclerosus and an increased risk of progression to invasive squamous cell carcinoma, compared with usual (HPV-positive) VIN.
Committee Opinion #509: Management of
vulvar intraepithelial neoplasia. Obstet Gynecol.
The agent has previously been reported as efficacious against
vulvar intraepithelial neoplasia (VIN), but "only in small, uncontrolled studies."
Vulvar intraepithelial neoplasia (VIN) and vaginal inrraepithelial neoplasia (VAIN) are not uncommon in women with HIV infection, and they often develop concurrently with high-grade cervical lesions.
In situ cases were classified as being
vulvar intraepithelial neoplasia 3,
vulvar intraepithelial neoplasia 2-3, or Bowen disease by the pathology report.
The recombinant vaccine, which is being marketed as Gardasil, is approved for the prevention of the following conditions caused by HPV types 6, 11, 16, and 18: cervical cancer, condyloma acuminatum, cervical adenocarcinoma in situ,
vulvar intraepithelial neoplasia grades 2 and 3, vaginal intraepithelial neoplasia grades 2 and 3, and cervical intraepithelial neoplasia (CIN) grades 1, 2, and 3.