XICS

(X Window interface to the Internet Chess Server) A graphical interface to the Internet Chess Server (ICS), which allows people to play chess over the Internet. X Window displays the chessboard and allows mouse moves rather than typing and receiving text. See ICS.

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Specifically, the AUC of the XIC of two unique peptides (Figures 2(a) and 2(c)) on NF-M were quantified and normalized to the average AUC of three peptides matching spinophilin in the spinophilin IPs.

Abbreviations 6-OHDA: 6-Hydroxydopamine AUC: Area under the curve CDK5: Cyclin-dependent protein kinase 5 D1R: Dopamine D1 receptor D2R: Dopamine D2 receptor DA: Dopamine HEK293: Human embryonic kidney 293FT cells MSN: Medium spiny neuron NF-M: Neurofilament medium PD: Parkinson disease PKA: Protein kinase A PKAc: PKA catalytic subunit PP1: Protein phosphatase 1 PSD: Postsynaptic density XIC: Extracted ion chromatogram.

(b) Quantification of the normalized AUC of the XIC matching the Ser17 in lesion and intact tissue normalized to the corresponding intact value.

Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction

This additive model on [log.sub.2] transformed peak areas is motivated from the assumption that electrospray XIC peak areas are proportional to the product of a peptide ion specific constant and sample concentration of the peptide ([AUC.sub.ij] ~ [P.sub.i][S.sub.j]).

Quantitative proteomics via high resolution ms quantification: capabilities and limitations

MRM-MS XICs that have been integrated with MultiQuant or Skyline are exported into comma-separated value (csv) files.

Use all transitions of a peptide (peak area from XICs) to calculate relative ratios by either the minimal pairs or all-pairs method.

Automated detection of inaccurate and imprecise transitions in peptide quantification by multiple reaction monitoring mass spectrometry