This last step is very slow thus resulting in accumulation of formic acid in the body which leads to life threatening metabolic
acidosis. Another postulated mechanism is the low hepatic levels of these enzymes in humans leading to methanol intoxication.
Prevalence of subacuteruminal
acidosis in Cattle and Buffaloes of district Okara and Lahore Punjab, Pakistan.
TRC101 represents a first-in-class drug candidate for the treatment of metabolic
acidosis, a chronic condition commonly caused by CKD that is believed to accelerate the progression of CKD, increase the risk of muscle wasting and cause the loss of bone density.
(3)
Acidosis occurs in most patients who are treated with topiramate.
Cows that suffer sub-acute rumen
acidosis reduce production triggered by inconsistent feed intake, poor feed efficiency and reduced feed digestibility.
The clinical signs presented in the current case, such as diarrhea, ruminal atony, and dehydration, were compatible with ruminal
acidosis and rumenitis (AFONSO & MENDONCA, 2007; GONZALEZ et al., 2014).
Arterial blood gas measurement revealed severe metabolic
acidosis (pH 7.12, Pa[O.sub.2] (arterial partial pressure of oxygen) 85 mmHg, PaC[O.sub.2] (arterial partial pressure of carbon dioxide) 12.8 mmHg, base excess -24.6, bicarbonate 7.3 mmol/L, lactate 2.1 mmol/L, albumin 32 g/dL, anion gap (AG) 26 mmol/L and blood glucose 5.4 mmol/L on 0.4 Fi[O.sub.2] (fraction of inspired oxygen).
The patient was orotracheally intubated due to metabolic
acidosis with high anion gap, which was treated using NaHC[O.sub.3].
A severe metabolic
acidosis was detected on arterial blood gas for which he received intravenous sodium bicarbonate.