a disease associated with disruption of the functioning of the anterior lobe of the hypothesis (adenohypophysis); it is accompanied by enlargement (broadening and thickening) of the wrists, feet, skull (especially the facial portion), and other parts. Acromegaly usually appears following maturation; its development is gradual, extending over many years. It is the result of excessive production of somatotropin. Analogous disruption of hypophysis activity in immature individuals is called gigantism. Acromegaly is accompanied by cephalalgia, fatigability, weakening of intellectual capacity, visual disorders, and frequently sexual impotence in men and amenorrhea in women. Its treatment consists of surgery of the hypophysis or roentgenotherapy.