Acute rejection is a cellular immune response of the recipient, which identifies the transplanted kidney as a foreign body.
Tacrolimus C [sub]0 and the risk of biopsy-proven
acute rejectionPatients at high-risk for
acute rejection received antibody induction therapy with anti-thymocyte antibodies and patients with post-operative oliguria or anuria received anti-IL2 receptor antibodies within 24 h of the transplant surgery.
"We showed that subclinical inflammation phenotypes were prevalent in pediatric kidney recipients without clinical dysfunction and were associated with increased
acute rejection and allograft failure," the authors write.
Four patients from the LRD group lost their graft, one six months after transplant due to recurrence of primary hyperoxaluria, the second lost her graft two years post-transplant secondary to
acute rejection. One child lost her graft because of polyoma (BK) nephropathy and the other secondary to chronic allograft nephropathy.
The presence of pretransplant DSA showed an odds ratio of 2.7 for
acute rejection and 17.7 for ABMR.
A 2012 study demonstrated a link between the number of
acute rejection episodes and HLA mismatches in VCA, though statistical significance was not achieved with the limited sample size [15].
During the follow-up period, a total of 65 episodes of gastrointestinal side effects, infections, and
acute rejection events were observed in 15 patients (23.0%), 10 patients (15.4%) and 7 patients (10.8%) respectively.
The increase in nonadherent behaviors puts the adolescent and young adult with a history of kidney transplantation at risk for
acute rejection of the transplanted kidney, which can lead to subsequent graft loss (Feinstein et al., 2005; Warady, Mudge, Wiser, Wiser, & Rader, 1996).
At least 5 pieces of well-expanded alveolated parenchyma are required for adequate morphologic evaluation of a transbronchial lung allograft biopsy specimen for
acute rejection. (11) To ensure that these recommendations are fulfilled, the bronchoscopist may need to sample more than 5 pieces.
Analysis focused particularly on the incidence and patterns of the early
acute rejection episodes, as well as one-year graft and patient survival.