In the brain, Firibastat causes the inhibition of
aminopeptidase A (APA) which is a key enzyme in the RAS.
CELTN active site conserved amino acids are same as that of FrvX
aminopeptidase (Fig.
siRNAs targeting the human Filamin B (Filamin B siRNA: sc-60641; Santa Cruz, CA, USA) the
Aminopeptidase N (CD13 siRNA: sc-29960; Santa Cruz), and a scrambled (siRNA-A control: sc-37007; Santa Cruz) mRNAs, were used to transfected BM-MSC cultures by means of Lipofectamine 2000 (Invitrogen, CA, USA) according to the manufacturer's protocol.
BF = bright field, 2D = grown on plastic, 2.5D = grown on transwell inserts, 3D = grown in matrigel sandwich, GGT1 = [gamma]-glutamyltransferase 1, LAP3 = leucine
aminopeptidase 3, ALPL = alkaline phosphatase.
Ibrahim, "Studies on acceleration of ras cheese ripening by
aminopeptidase enzyme from buffaloes' pancreas II- utilization of buffaloes' pancreas
aminopeptidase in acceleration of ras cheese ripening," New York Science Journal, vol.
(i) Tagging single-nucleotide polymorphisms (tSNPs) of the endoplasmic reticulum
aminopeptidase (ERAP) 1 and 2 is associated with baseline systolic and diastolic blood pressure (BP).
In lepidopteran larvae,
aminopeptidase N (APN) is one of at least 4 Cry1A protein-binding toxins (Bravo et al.
Proline
aminopeptidase activity as a rapid diagnostic test to confirm bacterial vaginosis.
Leuconostoc species are incapable of producing leucine
aminopeptidase and pyrrolidonyl arylamidase.
LNPEP, the gene which encodes the [AT.sub.4] receptor, but which may have a more important cellular function as insulin-regulated
aminopeptidase [30], was also expressed at a low level and its expression did not differ between normal lung tissue and lung tumor tissue.
The maturation of propeptides into functional peptides is performed during the vesicular transport within large dense-core vesicles (LDCVs) and requires the joint action of several endopeptidases (cathepsin L,
aminopeptidase B and E, and prohormone convertase 2) [21-23].