para-aminosalicylic acid
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para-aminosalicylic acid
[¦par·ə ə¦me·nō¦sal·ə¦sil·ik ′as·əd] (pharmacology)
C7H7NO3 White, crystalline drug used with other drugs in the treatment of tuberculosis. Abbreviated PAS.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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Table 8: Agents That May Cause Autoimmune Hemolytic Anemia * Stibophen * Phenacetin *
Aminosalicylic acid * Isoniazid * Rifampin * Sulfanamides and solfonylureas * Quinidine, quinine * Chlorpropamide * Immunosuppressants Table 9: Other Agents That May Cause Anemia * H2 blockers/proton pump inhibitors * Phosphate binders * Tetracyclines * Penicillins * Cephalosporins * Hydralazine * Phenacetin * Nitroglycerin * Vitamin K analogues * Sulfasalazine * Dapsone * Ribavirin * Alpha interferons Note: This article is supported by a financial grant from Amgen Inc.
Drug class Number Grade N (%) of users compliance Oral 5-ASA 128 Low 48 (37.5) Medium-high 80 (62.5) Immunomodulators 25 Low 7 (28) Medium-high 18 (72) Oral steroids 15 Low 6 (40) Medium-high 9 (60) Injectable biologics 16 Low 1 (6.3) Medium-high 15 (93.7) Intravenous 23 Low 1 (4.4) biologics Medium-high 22 (95.6) Low adherence (<6 points); medium-high adherence (6.1 to 8); N = numbers; MMAS-8 = modified Morisky Adherence Scale; 5-ASA = 5-
aminosalicylic acid; the use of MMAS is protected by US copyright laws.
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