The role of complement
anaphylatoxin C5a in neurodegeneration: implications in Alzheimer's disease.
Anaphylatoxin C5a receptor mRNA is strongly expressed in Kupffer and stellate cells and weakly in sinusoidal endothelial cells but not in hepatocytes of normal rat liver.
Table 3 (a) 12 upregulated MeDEGs identified in SSc HUGO (a) HUGO gene name (a): function (b) C3AR1 Complement C3a Receptor 1: Receptor for the chemotactic and inflammatory peptide
anaphylatoxin C3a.
In the case of immune mediated hemorrhage in the lung, the hypotheses for vessel leak are (1) vessel injury from neutrophil activation (e.g., through antineutrophil antibodies (ANCA associated vasculitis, AAV)), (2) immune complex deposition with activation of complement,
anaphylatoxin, and mast cells, or (3) abnormal lymphocyte inflammation and injury [14-16].
Afterwards, the Fc[epsilon]R and the
anaphylatoxin receptors (C5aR and C3aR), which bind with IgE, C5a, and C3a, respectively, the coactivation of the coagulation, and the kinin-kallikrein systems participate in the inflammation cascade [13].
ASP is identical to C3adesArg, the inactive fragment of the complement
anaphylatoxin peptide, C3a.
Vater, "Structural basis for the targeting of complement
anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer," Nature Communications, vol.
Complement activation from classical, alternative, and lectin pathways leads to production of the
anaphylatoxin C3a, a small polypeptide released from the precursor protein C3 by C3 convertases.