The classification of
antigenic determinants into epitopes and nonepitopes ignoring the antigen reconfiguration in Ag-Ab complex may not accurately reflect biological reality [3].
The [Centocor.sup.R] CA 72-4[TM} assay (Fujirebio Diagnostics, Inc./Centocor, Inc.) is a solid phase radioimmunoassay (CA 72-4) (RIA) based on two monoclonal antibodies, cc49 and B72.3, which react with distinct
antigenic determinants on a tumor associated glycoprotein TAG 72.
coli and the antiserum containing the F18 specific
antigenic determinant "a" were mixed and the agglutination reaction was observed.
Focusing on the epitope information, using N protein-specific mAbs we thoroughly mapped the
antigenic determinants distributed on the SARS-CoV N protein.
Despite the extensive use of PSA as a clinical marker of prostate cancer, much is yet to be learned about the
antigenic determinants on the PSA molecule (15).
Cross-reactivity experiments indicated that the amino acid sequence -Xaa-Pro-Thr-COON (where Xaa is a basic amino acid) at B28-B30 is the
antigenic determinant. First, modifications to this region produced the greatest disruption in antigenicity (Table 1), and native human insulin displays cross-reactivity.
This base could expose the sugar epitopes, leaving them available as
antigenic determinants to induce specific IgE production [4,9].
In Figure 7(1B), the two peaks of antigenicity are located on the surface of the protein with higher score in green color and, additionally, its active center in red color is observed, corresponding to the information registered on the
antigenic determinants in Table 5.
Recombinant core particles of hepatitis B virus exposing foreign
antigenic determinants on their surface.
Full length Hexon carries type, group and subgroup specific
antigenic determinants, whereas, hypervariable region of hexon contains type specific antigenic regions.