Effect of different casein concentration on L-
asparaginase production by all isolates is as shown on Figure 12.
Asparaginase is an FDA approved drug for lymphoblastoid leukemia, and has never before been applied to treat GAS infections.
Jazz Pharmaceuticals markets SunosiTM (solriamfetol), Xyrem (sodium oxybate) oral solution, Defitelio (defibrotide sodium), Erwinaze (
asparaginase Erwinia chrysanthemi) and Vyxeos (daunorubicin and cytarabine) liposome for injection in the U.S.
Best practices in adolescent and young adult patients with acute lymphoblastic leukemia: a focus on
asparaginase. J Adolesc Young Adult Oncol 2015; 4(3): 118-28.
"This approval underscores Shire's commitment to patients with acute lymphoblastic leukaemia through continued research and evolution of
asparaginase therapy," said Howard B.
Asparaginase (asparagine amidohydrolase EC 3.5.1.1) hydrolyzes the amino acid asparagine into aspartic acid and ammonia.
Hematologists, oncologists, pediatricians, and other clinicians from North America, Asia, and France cover the history of its treatment, its epidemiology and etiology, diagnosis and classification, molecular pathogenesis, cytogenetics, chemotherapy for adults and children, the use of
asparaginase, the monitoring of minimal residual disease to guide therapy, prophylaxis and treatment of central nervous system involvement, pharmacogenomics and chemotherapy, hematopoietic stem cell transplantation, long-term complications of therapy, and new treatment agents, including bispecific T-cell engaging antibodies and autologous antigen receptor expressing T-cells.
A pink zone was observed around the colonies suggesting that endophytic fungi were able to utilize the substrate asparagine by secreting the enzyme
asparaginase which catalyzes the breakdown of the substrate (Figure 3).
The pre-treatments included the use of food acids, salts and the enzyme
asparaginase. Although these components significantly reduced acrylamide levels during laboratory experiments, their application on an industrial scale did not result in further acrylamide reductions in pre-frozen fries.
Asparaginase is the enzyme that hydrolyzes asparagine into L-aspartic acid and ammonia.