In each case, 1 [beta]g of each
bile acid sulfate was incubated with 10 mL sodium acetate buffer (0.05 M, pH 4.6 or 6.2) and enzyme (0.1 mL) at 37[degrees]C overnight in a shaking water bath.
Bioassays of total cholesterol and
bile acids in the feces
Selective oxidations and acylations in the
bile acid series," Journal of the American Chemical Society, vol.
The term ICP was used if the serum
bile acid level was [greater than or equal to]10 [micro]mol/L with pruritus that could not be explained by any other condition.
BASD accounts for about 2% of neonatal cholestasis cases, and early primary
bile acid replacement treatment can achieve good results.
(8,12) Finally, cholesterol is transformed into
bile acid and efflux outside of the body, which is also an important cholesterol-eliminating way and the transformation is mainly controlled by cholesterol 7alpha-hydroxylase (CYP7A1).
Albireo Pharma is a clinical-stage biopharmaceutical company focused through its operating subsidiary on the development of novel
bile acid modulators to treat orphan pediatric liver diseases, and other liver and gastrointestinal diseases and disorders.
The condition causes the build-up of
bile acids in the blood, and symptoms include itching, often severe.
According to the company, Maralixibat is an inhibitor of the apical sodium-dependent
bile acid transporter (ASBT), which recycles
bile acids from the intestine to the liver.
Bile acid malabsorption can cause diarrhea or loose stools.
Albireo Pharma announced that clinical data from a Phase 2 study of lead product candidate odevixibat or A4250, a highly potent and selective inhibitor of the ileal
bile acid transporter, IBAT, in biliary atresia, Alagille syndrome and progressive familial intrahepatic cholestasis, PFIC, were presented today at the 2019 European Society for Paediatric Gastroenterology, Hepatology and Nutrition Annual Meeting in Glasgow, Scotland.