Jo Realising they had identified a process with huge commercial potential internationally the research team, led by Professor Jo Bradwell, created the
Binding Site as a commercial venture.
It is easy to grasp then how a mutation within a promoter, changing a TF
binding site, can lead to problems not through a change in the function of the mature gene product, but through variation in expression level of the product.
The
binding site prediction is also very important for target drug design.
Positions of the amino acids present in
binding site of the protein and tertiary structure representation of the
binding site were determined by FTsite server from Boston University, which is freely available online at http://ftsite.bu.edu/.
Conventional stepwise complex formation algorithm best fits the data matrix which included one strong
binding site and one weak
binding site (lg [K.sub.1-2] = [7.07 5.79]), lof([A.sub.3e]) [approximately equal to] 0.25%.
It contains tryptophan and tyrosine in the
binding site. The Y469 formed CH/pi stacking with Glc2 and W460 formed stacking with Glc4.
[15] reported that in patients with advanced liver disease, the reduction of binding capacity at albumin
binding site II that binds to aromatic carboxylic compounds is related to impaired liver function.
It is notable that a 200-bp region immediately upstream of the transcription start site contained highly conserved transcription factor-binding motifs, including the Oct4/Sox2
binding site and Sp1 binding motifs.
Data from laboratories running Optilite show 40% faster processing of complex protein assays compared to other special protein analyzers on the market,
Binding Site said.
Further investigation helped to elucidate the stereochemical specificity of the carbohydrate
binding site to the bacterial ligand.