Vascular congestion, epithelial loss and hyaline membrane formation, degenerations and necrosis in
bronchiolar and alveolar cell walls, thickening in interalveolar septum, congestion in capillary walls, mononuclear cell infiltrations can be observed with light microscope (Odabasi,D.2006; Schnells et al.
Five days after inhalation, WD large
bronchiolar inflammatory infiltration was observed and consisted of more than 100 layers of cells (Photo 2a).
At all time points, scattered immunopositive
bronchiolar epithelial cells were observed (arrows).
However, unexpectedly, the results showed that TAZ expression in fibroblasts and
bronchiolar cells was significantly lower in fibrotic type versus cellular type [Figure 1]a and [Figure 1]b.
Toxicokinetics affecting concentrations at the
bronchiolar epithelium substantially drive the risk of bronchiolitis obliterans from irritant gases.
Pathologically, cryptogenic organizing pneumonia was defined by the presence of granulation tissue in the
bronchiolar lumen, alveolar duct, and some alveoli, associated with a variable degree of interstitial and air space infiltration by mononuclear cells and foamy macrophages [1-3].
The entrapped
bronchiolar epithelium was highlighted by AE1/AE3 (Figure 5(i)).
In all WT mice exposed to NA inhalation, airway epithelial cell necrosis was clearly visible in the lung using high-resolution light microscopy, at both time points after termination of exposure, with partial detachment of Club (Clara) cells from the
bronchiolar epithelium.
Babb and Rodarte [24] have reported that mean
bronchiolar diameter decreases after the age of 40.
The lymphocytes infiltrated
bronchiolar epithelium forming well-defined lymphoepithelial lesions.