guanosine

[′gwän·ə‚sēn]

(biochemistry)

C₁₀H₁₃O₅N₅ Guanine riboside, a nucleoside composed of guanine and ribose. Also known as vernine.

The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Guanosine

the nucleoside consisting of the carbohydrate ribose and the nitrogen base guanine. Colorless crystals. Molecular weight, 283.26 and melting point. 235° C. Free guanosine is an intermediate product of metabolism. It is a component of nucleic acids and biologically active guanyl nucleotides, GMP, GDP. and GTP. GTP (guanosine triphosphate), an energy-rich phosphorus compound, is a coenzyme of some reactions, such as the amination of inosinic acid and the transference of amino acids to ribosomes during the biosynthesis of protein.

Mentioned in

References in periodicals archive

Comments: The Pharmaceutical cGMP requirement is more specific in this section, stating the containers and closure should not be reactive, additive, or absorptive.

Comparing cGMP Pharma vs. Device: Subpart E--Control of Components, Containers and Closures

Comments: In my opinion, the pharmaceutical cGMP regulation does a much better job of defining the term specification.

Comparing CGMP Pharma vs. Device: Subpart A--General Provisions (Part II)

A Certificate of Completion will also be provided to help meet the cGMP requirement that QC/QA personnel be adequately trained in dietary ingredient testing.

Identity testing doesn't need to be expensive to be valid: AHPA and AHP will present a hands-on workshop at Portland State University in Oregon on June 15-16

In addition, tolerance to morphine has been associated with increased cGMP levels in various brain regions (Bhargava & Cao, 1997).

Effects of phosphodieastrase type 5 inhibitions on morphine withdrawal symptoms in mice

During hyperpolarization in nonsaturating light, the partial current suppression caused by intracellular cGMP reduction will be counteracted by the increase in the residual cGMP-gated current caused by its inward rectification properties, which will ultimately reduce the voltage response to light of the cone cells.

Cone-like rectification properties of cGMP-gated channels in transmutated retinal photoreceptors of nocturnal geckoes

PDE5,6, and 9 are considered cGMP specific PDE, whereas PDE4,7, and 8 mainlyhydrolyze cyclic AMP (cAMP) and PDE1, 2, 3, 10, and 11 hydrolyze both substrates (reviewed in [14]).

Stimulation of neural stem cell proliferation by inhibition of phosphodiesterase 5

The lab is intended to enable the company to concentrate more on customers' needs for smaller quantities of material, specifically produced to cGMP guidelines.

-Albemarle expands kilo lab at South Haven, Michigan

WORLDWIDE COMPUTER PRODUCTS NEWS-October 22, 2012-WuXi AppTec hosts Global Monoclonal Antibody Summit following opening of first cGMP biologics facility in China(C)1995-2012 M2 COMMUNICATIONS http://www.m2.com

WuXi AppTec hosts Global Monoclonal Antibody Summit following opening of first cGMP biologics facility in China

A twin-screw extruder within the company's Class 7 cGMP clean room is designed to produce development PEEK compound batches as small as 5 lbs (2.27 kg) through production quantities, Foster says.

Foster Delivery Science, a business unit of Foster Corp. that specializes in contract development and manufacturing of implant and drug-delivery polymers, reports that it now offers custom radiopaque PEEK compounds for use in longterm orthopedic implants