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camptothecin

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camptothecin

[‚kam·tō′thē·sən]
(pharmacology)
An alkaloid belonging to the family of drugs called topoisomerase inhibitors which is used as an anticancer drug, it is the first known naturally produced DNA topoisomerase inhibitor and was originally isolated from the Chinese tree Camptothecin acuminate.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive
It has been used to extract camptothecin and hydroxycamptothecin from Camptotheca acuminata leaves [17] and isoflavones from soybean meal [18], which has been proved to be an effective extraction method.
The utility of camptothecin as a synergist of Bacillus thuringiensis var.
Present study presented the inhibitory effect and mechanism of the plant alkaloid camptothecin on R.
There are a number of medicines derived from plants such as vinblastine, vincristine, Madagascar periwinkle, capsaicin from chili pepper, and paclitaxel from Pacific yew while few chemically altered lead molecules derived from plants are dicoumarol (warfarin), artemisinin (artemether), camptothecin (irinotecan and topotecan), morphine, and salicylic acid (acetylsalicylic acid).
Uniform spherical nanoparticles with BSA-PMMA core and layers were prepared by precipitation to encapsulate camptothecin. The camptothecin-loaded BSA-PMMA nanoparticles showed antitumor activity improvement in both in vitro and in vivo studies, reducing the tumor growth around 79%, being more effective than free drug.
Cyclodextrin-based nanosponges encapsulating camptothecin: Physicochemical characterization stability and cytotoxicity.
Some endophytic fungus can produce alike biological active compounds as the host, for example taxol (Stierle et al.,1993), capsaicin (Devari et al., 2014) and piperine (Chithra et al., 2014) and some produce drug like camptothecin (Singh et al., 2013) etc.
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