Influence of a combination of two tetrachlorobiphenyl congeners (PCB 47; PCB 77) on thyroid status,
choline acetyltransferase (ChAT) activity, and short- and long-term memory in 30-day-old Sprague-Dawley rats.
Inhibitors of nitric oxide synthase attenuate nerve growth factor-mediated increases in
choline acetyltransferase expression in PC12 cells.
Choline acetyltransferase activity and histopathology of frontal neocortex from biopsies of demented patients.
In the mammalian brain, choline transport, and not the activity of
choline acetyltransferase, is the rate-limiting step in ACh biosynthesis and the locus of regulation of ACh levels (Klemm and Kuhar 1979; Simon et al.
Postmortem studies have found a reduction in
choline acetyltransferase activity in the cortex, hippocampus, and striatum, suggesting reduced nicotinic receptors in those regions.
10:00 EFFECTS OF A COPLANAR CONGENER PCB 77 (3,3', 4,4'-TETRACHLOROBIPHENYL) ON
CHOLINE ACETYLTRANSFERASE ACTIVITY AND CIRCULATING THYROXINE ([T.sub.4]) AND TRIIODOTHYRONINE ([T.sub.3]) IN 30-DAY-OLD SPRAGUE-DAWLEY RATS.
There are parallel deficits in the enzyme
choline acetyltransferase, responsible for cholinergic neurotransmitter formation, and in the transmitters norepinephrine and 5-hydroxytryptamine.