SMC1/3 form the core of the cohesin complex which mediates sister chromatid cohesion; SMC2/4 are present in the condensin complex that acts in chromosome assembly and segregation.
Furthermore, since the Nesprin-2 condensin interaction also takes place during other phases of the cell cycle and since condensins have additional functions in interphase, the Nesprin-2 condensin complex could also affect these processes.
Carroll et al., "Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis," Genes & Development, vol.
As the chromosomes condense, REC8 is cleaved on the chromosome arms and the cohesin complex is replaced by the
condensin complex. The crossover point remains to ensure proper alignment, tension, and segregation of the homologous chromosomes.