Congenital hypothyroidism clinical aspects and late consequences.
Screening for
congenital hypothyroidism: results of screening one million North American infants.
They speculated that delays in detecting primary
congenital hypothyroidism could be caused by the suppression of TSH secretion as a result of "hypothalamic-pituitary immaturity, medication administration, and effects of serious neonatal illness." In fact, had standard, recommended 2-week-only screening protocols been followed with their patient population, fully 48% of infants with delayed TSH elevation would have been overlooked; half of these patients were later found to have de-compensated hypothyroidism.
Among 130 confirmed cases of
congenital hypothyroidism identified in Utah during 2010-2016, 123 cases with two screens were analyzed, including 98 cases identified by the first screen and 25 cases identified by the second screen; seven of the 130 cases were excluded because only one test result was available.
[4] Prolonged jaundice can be associated with
congenital hypothyroidism, which appears to be associated with the delayed maturation of hepatic uridine diphosphate glucuronyl transferase enzyme activity.
It has an impact upon growth and development of children and is the most common cause of mental impairment globally.6 When daily intake reaches below 25 ugm
congenital hypothyroidism is evident.6,7 Mental retardation due to
congenital hypothyroidism can be prevented by early diagnosis by newborn screening and immediate treatment.8
Congenital hypothyroidism is one of the most common congenital diseases, with an incidence of 1/4,000 newborns.
Our case had
congenital hypothyroidism. Ectopic thyroid tissue was incapable of providing the thyroid hormone needs.
Silva, "
Congenital hypothyroidism: etiology," Journal of Pediatric Endocrinology and Metabolism, vol.
Conclusion: The frequency of
Congenital Hypothyroidism is notably higher in pediatric community than reported in most other countries.
There is usually no cure for
congenital hypothyroidism, but replacement therapy and continued monitoring will ensure proper growth and development of the infant.
Congenital hypothyroidism (CH) is the most common congenital endocrine disease in childhood and is also a preventable cause of mental deficiency, affecting about one in 3,000-4,000 live births [1,2].