Sharma, "
Cyclin-dependent kinase 5/p35/p39: a novel and imminent therapeutic target for diabetes mellitus," International Journal of Endocrinology, vol.
Squires et al., "A phase I pharmacokinetic and pharmacodynamic study of AT7519, a
cyclin-dependent kinase inhibitor in patients with refractory solid tumors," Annals of Oncology, vol.
Uldrijan, "
Cyclin-dependent kinase inhibitors as anticancer drugs," Current Drug Targets, vol.
p21WAF1 (p21) and p27KIP1 (p27) are both universal inhibitors of
cyclin-dependent kinases and can therefore influence cell cycle or tumor progression.
Pines, "
Cyclin-dependent kinase inhibitors: the age of crystals," Biochimica et Biophysica Acta--Reviews on Cancer, vol.
MJ-29 inhibits tubulin polymerization, induces mitotic arrest, and triggers apoptosis via
cyclin-dependent kinase 1-mediated Bcl-2 phosphorylation in human leukemia U937 cells.
Cyclin D1 regulates G1 phase progression via
cyclin-dependent kinase 4/6-dependent phosphorylation and partial inactivation of the repressive activity of the retinoblastoma protein.
GW8510 inhibits the enzyme
cyclin-dependent kinase 2, which helps trigger cell division and attracts chemotherapy drugs.
Where indicated, patients must have received endocrine therapy with or without a
cyclin-dependent kinase 4/6 inhibitor.
Syros Pharmaceuticals announced that data from the dose escalation portion of its Phase 1 trial of SY-1365, its first-in-class selective
cyclin-dependent kinase 7 inhibitor, demonstrated proof-of-mechanism at tolerable doses in patients with advanced solid tumors.